E – Endothelial tight junctions’ permeability is increased in response to injury and inflammation, allowing migration of white blood cells and friends to the site of injury.Ovarian carcinoid is highly unlikely to show up on your test, but if it did, it would likely present with a classic carcinoid syndrome. Teratomas are oddballs that typically have fat, hair, teeth, etc. Granulosa cell tumors, on the other hand, sometimes produce estrogen (which can lead to precocious puberty in young girls but otherwise may be occult). Leydig cell tumors aren’t always physiologically active, but those that are can cause masculinization. Patients with cancer are hypercoagulable. That’s why he came to the ER in the first sentence and what the ultrasound shows at the end. The issue of the day is that he has a DVT. B – Don’t let them blind you with this patient’s misery.There is no randomization as there is only a single treatment group. If you know you are getting a drug, then you are not blinded: it’s an open-label trial. C – This is obviously a clinical trial.Logically, resting muscle requires less energy (and thus less need for fatty acid breakdown) than active muscle. A – Malonyl-CoA inhibits the rate-limiting step in the beta-oxidation of fatty acid.T-cell CD28 activation through binding CD80 (part of the B7 group) on the APC is the dominant interaction in T-cell hypersensitivities/allergies. B – Contract dermatitis is a type IV (T-cell mediated) hypersensitivity. And yes, even someone who uses and/or is dependent on illicit drugs should also receive narcotics to control pain. (Very) short-term use (immediately post-surgical) does not lead to long-term dependence (or so people have thought…).
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